Leadoptimization相关论文
Discovery of Pteridin-7(8H)-one-based Inhibitors Targeting FMS-like Tyrosine Kinase 3(FLT3)and Its M
FMS-like tyrosine kinase 3(FLT3)is validated as a therapeutic target for AML treatment1.We firstly reported pteridin-7(8......
Multi-Criteria Molecular Design:What can we learn from recent successes? Lead Hopping,Scaffold Hoppi
Multiple biological and physical-chemistry parameters contribute to a commercially successful drug or agchem discovery p......
Docking-based virtual screening of large compound libraries has been widely applied to the early stage of lead discovery......
An Efficient and Versatile Tool for Lead Structure Generation and Optimization in Structure-based Dr
In structure-based drug design,docking-based virtual screening is widely applied to lead discovery.Other types of method......
Cellular Targets Identification and Lead Optimization of Natural Small-Molecule STAT3 Inhibitors Tar
Signal transducer and activator of transcription 3(STAT3) is an oncogene constitutively activated in many human cancers[......
Discovery of LspA Inhibitors as Novel Antibacterial Agents:Virtual Screening,Synthesis and Biologica
The emergence and spread of antibiotic resistance represent a severe global issue.New drug targets and novel lead compou......
Docking-based virtual screening of large compound libraries has been widely applied to the early stage of lead discovery......
Discovery of Novel Antibacterial Agents by Structure-based Drug Design, Synthesis and Biological Eva
The emergence and spread of antibiotic resistance represent a severe global issue.New drug targets and novel lead co......
